H332 Harmful … 12 Skincare Ingredients You May Want to Avoid .  |  _____ Page 2 / 8 _____ Diethylene glycol dimethyl ether Revision Date 14-Feb-2020 Inhalation Remove to fresh air. The majority of glycol ethers are of low acute toxicity; the main effect seen in laboratory animals at high doses is narcosis, typical of many solvents. Objectives: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol ethers in vitro. Caprylyl Glycol. There are no data available for the effects of repeated exposure to diethylene glycol monoethyl ether. Methods: Skin permeation was calculated using the Franz cell method with human skin. The appearance of glycol ether … In the case of solvents with high dermal absorption, the air concentration is no longer a sufficient measure of the total exposure to workers, and therefore merely respecting threshold limit values (TLVs) in the air is not necessarily enough to protect them. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. Glycol ethers are a large group of organic solvents used in industry and the home as glass cleaners, carpet cleaners, floor cleaners and oven cleaners. Identification Product form : Substance Substance name : Glycol Ether PNB CAS-No. Effect of ethylene glycol monobutyl ether on skin layer formation kinetics of asymmetric membranes As a consequence, several approaches have been proposed to overcome the skin barrier, such as the inclusion of penetration enhancers in the topically applied drug solutions and emulsions. The opinion relates to the dermal application. 2003 Jun;76(5):382-6. doi: 10.1007/s00420-002-0429-y. National Library of Medicine,. 2007 Jan 15;218(2):128-34. doi: 10.1016/j.taap.2006.09.019. Glycol Ether EB. However, prolonged or excessive application can cause redness and itching to sensitive skin. The presence of acetone in the solution caused a reduction in lag time and an increase in permeation rate, higher for EGMEE, lower for EGDEE, indicating the enhancing effect of this mixture of solvents. Indeed, it acts causing the swelling of … 2017 Nov;91(11):3587-3596. doi: 10.1007/s00204-017-2046-2. Ethereal. 2015. It is liable to form peroxides on exposure to air and light. Experience with human exposure to ethylene glycol monomethyl ether has indicated that it can result in the appearance of immature leucocytes, monocytic anaemia, and neurological and behavioural changes. Applications. H302 Harmful if swallowed. US. Hum Exp Toxicol. However, since the most used glycols are liquid, the skin is the major route of entry into the body. Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Local effects on skin and mucous membranes. Glycol Ether EB Safety Data Sheet according to Federal Register / Vol. H336 May cause drowsiness or dizziness. Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Glycol ethers may be used in any food-related application (such as coatings or printing inks) without regard to specific FDA regulations if subsequent processing steps, such as washing, drying, vaporizing, heating, purging, etc., are adequate to completely remove all traces of the solvent. P-series glycol ethers are marketed as having lower toxicity than the E-series. Toxicol Appl Pharmacol. PGBE is the only propylene glycol ether classified as a moderately skin irritant . HAZARDS IDENTIFICATION Appearance and Odor: Clear. This misconception comes from its uses outside of the skincare industry. Safety Data Sheet. Some glycol ethers are eye irritants. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Korinth G(1), Göen T, Lakemeyer M, Broding HC, Drexler H. Author information: (1)Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine, University Erlangen-Nuremberg, Erlangen, Germany. The ACGIH recommends a TLV-TWA of 100 ppm and a TLV-STEL of 150 ppm, with a skin notation, for this colorless liquid with a mild, pleasant, ethereal odor and a bitter taste. Normal use of these products is not dangerous or toxic to the skin or airways. Most glycol ethers are water-soluble, biodegradable and only a few are considered toxic. Skin permeation was calculated using the Franz cell method with human skin. HK- GLE26 is used in skin care, baby care, shampoos, bath and shower products... view more. Handling and storage Handling Wear personal protective equipment/face protection. Such treatments should remove solvent residues that could be considered food additives. Transcutol has no positive effects on diclofenac nanosuspension skin penetration. The invention discloses a preparation method of glycol ether. For all solvents tested the lag time was less than 2 h, and for the majority of them was about 60 min. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. 77, No. Epub 2003 Jun 19. They are absorbed as volatile fumes from the air by the skin as well as inhalation. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Venier M, Adami G, Larese F, Maina G, Renzi N. Toxicol In Vitro. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Please enable it to take advantage of the complete set of features! The nanosuspensions were characterized by different techniques such as scanning electron microscopy, differential scanning calorimetry, X-ray powder diffractometry, Fourier-transform infrared spectroscopy and photon correlation spectroscopy. Glycol Ether PNB Safety Data Sheet according to Federal Register / Vol. the breakdown. Do not get in eyes, on skin, or on clothing. GLYCOL ETHERS can react with both oxidizing agents and reducing agents (such as aluminum or lithium aluminum hydride). ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. EWG Skin Deep® | What is PROPYLENE GLYCOL BUTYL ETHER EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. Table 1. Skin strain and its influence on systemic exposure to a glycol ether in offset printing workers. eCollection 2018. It has been suggested that TRC can lead to the formation of a cutaneous depot of topically applied drugs due to its ability to increase skin permeability. It attacks some forms of plastics, rubber and coatings. doi: 10.1371/journal.pone.0205458. H319 Causes serious eye irritation. 2004 Feb;77(2):85-9. doi: 10.1007/s00420-003-0455-4. Glycol ethers are solvents widely used alone and as mixtures in industrial and household products. Objectives: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol ethers in vitro. Attracts water: Zeichner says at low concentrations, propylene glycol acts like a humectant, which means it binds water and pulls in hydration to the outer skin layer.When used in cosmetic products, it helps give the skin a hydrated, dewy appearance. Caprylyl Glycol (and) Ethylhexylglycerin. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Nanocrystal suspension of diclofenac increases its dermal bioavailability. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Symptoms may include pain, headache, nausea, vomiting, dizziness, drowsiness and other central nervous system effects. Name: Glycol Ether EE Synonyms: 2-ethoxyethanol; ethylene glycol monoethyl ether; ethylene glycol ethyl ether; EE CAS# 110-80-5 ... P303, P361, P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. The word "Cellosolve" was registered in 1924 as a United States trademark by Carbide & Carbon Chemicals Corp. for … The effect of diethylene glycol monoethyl ether (DGME; Transcutol) on the permeation of ivermectin, a broad-spectrum antiparasitic agent, through bovine skin was evaluated byin vitro permeation experiments followed by serial sectioning of the skin to assess the amount of ivermectin retained in the skin. Nanosized diclofenac maintains the same polymorphic form of the bulk drug. Applications. Also, like other organic solvents, glycol ethers can dissolve your skin's natural protective oils, causing dryness, redness, flaking, cracking, and dermatitis (skin rash). Epub 2003 May 9. 2002 Oct;75(8):519-27. doi: 10.1007/s00420-002-0367-8. The ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. The Glycols produced mild to severe ocular irritation when tested in rabbits, with Hexylene Glycol produc- ing the most severe irritation. Although ethylene glycol monomethyl ether is not appreciably irritating to skin, it can be absorbed in toxic amounts. A physiological solution was used as the receiving phase. In patch tests, 20% diethylene glycol ethyl ether in petrolatum did not cause irritation in 25 volunteers after 48‐hour occlusive application. H315 Causes skin irritation. Would you like email updates of new search results? Boiling GCcolumn Molecular point, temperature, Compound Synonym Abbreviation weight °C °C 2-Methoxyethanol Ethylene glycol monomethyl ether EM 76 124 150 2-Ethoxyethanol Ethylene glycol monoethyl ether EE 90 135 140 2-Ethoxyethyl Ethylene glycol acetate monoethyl ether acetate EEAc 132 156 180 Korinth G, Geh S, Schaller KH, Drexler H. Int Arch Occup Environ Health. H312 Harmful in contact with skin. Overall, the present results exclude a synergistic effect of the nanosizing approach and the addition of diethylene glycol monoethyl ether in regard to the skin penetration of diclofenac applied as a nanosuspension. 1994 May;13(5):325-35. doi: 10.1177/096032719401300508. The gelation rate constant decreased with the increase of concentration of EGME. Use only under a chemical fume hood. Ingestion If swallowed, seek medical advice immediately and show this . Rinse skin with water or shower. 77, No. BACKGROUND A risk assessment of EGBE with the chemical name 2-butoxyethanol or ethylene glycol monobutyl ether was done by a member state (France). May attack some plastics, rubber and coatings (NTP, 1992). HHS In vitro evaluation of the efficacy of skin barrier creams and protective gloves on percutaneous absorption of industrial solvents. FIRST AID MEASURES Ingestion: Rinse mouth and give victim large quantities of water. Liquid. Dow . Glycol Ether PNB Safety Data Sheet according to Federal Register / Vol. Precautionary statements. Never give anything by mouth to an unconscious person. H315 Causes skin irritation. There are no data available for the effects of repeated exposure to diethylene glycol monoethyl ether. Experience with human exposure to ethylene glycol monomethyl ether has indicated that it can result in the appearance of immature leucocytes, monocytic anaemia, and neurological and behavioural changes. Data on chemically related PPG Butyl Ethers were reviewed as a further basis for the assessment of safety. In this work, the penetration enhancer diethylene glycol monoethyl ether was included in novel diclofenac acid nanocrystal formulations, developed using the wet media milling technique and Poloxamer 188 as … Schenk L, Rauma M, Fransson MN, Johanson G. PLoS One. Both E-series glycol ethers and P-series glycol ethers can be used as intermediates that undergo further chemical reactions, producing glycol diethers and glycol ether acetates. A permeation profile was obtained and steady state, lag time and permeation constant flux was calculated for each of the following solvents: ethylene glycol monoethyl ether … P264 - Wash Skin thoroughly after handling P270 - Do not eat, drink or smoke when using this product . the good: It is used to improve the texture and stability of a formulation. Dipropylene Glycol. Some glycol ethers are eye irritants. In patch tests, 20% diethylene glycol ethyl ether in petrolatum did not cause irritation in 25 volunteers after 48‐hour occlusive application. Marek EM, Koslitz S, Weiss T, Fartasch M, Schlüter G, Käfferlein HU, Brüning T. Arch Toxicol. Methods: Skin permeation was calculated using the Franz cell method with human skin. Skin contact Wash off immediately with plenty of water for at least 15 minutes. PPG-33-Buteth-35. USA.gov. LABEL ELEMENTS . Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. Ingestion of propylene glycol could cause irritation, burning sensations to the throat and mouth, nausea and vomiting. Glycol ethers may be used in any food-related application (such as coatings or printing inks) without regard to specific FDA regulations if subsequent processing steps, such as washing, drying, vaporizing, heating, purging, etc., are adequate to completely remove all traces of the solvent. Percutaneous absorption of 5 glycol ethers through human skin in vitro. 2004 Oct;18(5):665-71. doi: 10.1016/j.tiv.2004.03.004. : 5131-66-8 Formula : … This site needs JavaScript to work properly. Clinical toxicology of ethylene glycol monoalkyl ethers. These solvents typically have a higher boiling point, together with the favorable solvent properties of lower-molecular weight ethers and alcohols. 2005 Mar 28;156(1):181-8. doi: 10.1016/j.toxlet.2003.09.023. METHODS: Skin permeation was calculated using the Franz cell method with human skin. Jeen International . Who is it for? Toxicol Lett. : 5131-66-8 Formula : … The invention discloses a preparation method of glycol ether. H302 Harmful if swallowed. P304, P340 . The Franz method might be helpful for obtaining a grading of skin notation for hydrophilic substances: in the case of glycol ethers, it can give us precise information about permeation risk, particularly important in the evaluation of exposure. glycol monoethyl ether (DEGEE) in all cosmetic products, except products for oral hygiene and eye products at a concentrations up to 1.5% does not pose a risk to the health of the consumer, provided that the level of ethylene glycol in DEGEE used is < 0.2%. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. Appears as: listid: HMAP-0688; Chemical_Name: Glycol ethers; Synonyms: Cellosolve solvents; Classified as not expected to be potentially toxic or harmful: Environment Canada Domestic Substance List: Classified as a low human health priority: Environment Canada Domestic Substance List The influence of water mixtures on the dermal absorption of glycol ethers. New toxicity data for the propylene glycol ethers - a commitment to public health and safety. © 2017 Elsevier B.V. All rights reserved. Diethylene glycol monoethyl ether (Transcutol ® P, TRC) seems to be very attractive as skin penetration enhancer due to its non-toxicity, biocompatibility, miscibility with polar and non-polar solvents . SDS Number: 100000002203 2 / 12 Glycol Ether EB. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 06/21/2018 Revision date: 06/21/2018 Supersedes: 11/30/2017 Version: 2.1 06/21/2018 EN (English US) Page 1 SECTION 1: Identification 1.1. Clipboard, Search History, and several other advanced features are temporarily unavailable. Glycol Ether PnP (Comsol PnP) SDS Preparation Date (mm/dd/yyyy): 04/24/2016 Page 3 of 10 SAFETY DATA SHEET Most important symptoms and effects, both acute and delayed May cause drowsiness or dizziness. Epub 2002 Aug 27. We use cookies to help provide and enhance our service and tailor content and ads. H312 Harmful in contact with skin. ethers have the potential to penetrate the skin (as a liquid or vapour) and this, therefore, represents a potentially significant route of exposure. 77, No. Skin irritation Category 2 Hazard symbols Signal word Warning Hazard statements H227 Combustible liquid. Transcutol increases particle size and reduce diclofenac nanosuspensions solubility. Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. GLYCOL ETHER DB 1. Call a physician immediately. Absorption of Some Glycol Ethers Through Human Skin in Vitro by Paul H. Dugard,* Michael Walker,* Susan J. Mawdsley' and Robert C. Scott* Tb assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. glycol, and Dipropylene Glycol caused minimal to mild irritation of rabbit skin, whereas Hexylene Glycol was moderately irritating. Local effects on skin and mucous membranes. Flux at steady state ranged between 0.017 +/- 0.005 and 3.435 +/- 1.897 mg/cm(2)/h and permeation rate was from 0.0192 to 1.02 x 10(-3) cm/h. Do not ingest. Butyl Glycol Ether Revision Date 09/05/2019 Version 2.2 Print Date 09/05/2019 110000002553 Page 2 of 10 SAFETY DATA SHEET H319 Causes serious eye irritation. Absorption of Some Glycol Ethers Through Human Skin in Vitro by Paul H. Dugard,* Michael Walker,* Susan J. Mawdsley' and Robert C. Scott* Tb assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. The amount of solvent passing through the skin was analysed with a gas chromatographic technique employing flame ionization detection. Glycol ether is prepared in a high selectivity manner with glycol as a raw material, low carbon fatty alcohol as an etherification reagent and a reaction solvent and an acid as a catalyst. Int Arch Occup Environ Health. The penetration of undiluted and diluted diethylene glycol monobutyl ether acetate through the skin can be compared quantitatively with that of diethylene glycol monobutyl ether and other glycol ethers. Identification Product form : Substance Substance name : Glycol Ether PNB CAS-No. Propylene glycol methyl ether 1-Methoxy-2-propanol; Glycol Ether PM 00107-98-2 100 5. Our results confirm the high percutaneous absorption of the GEs tested. Ethylene glycol methyl ether acrylate, stabilized Revision Date 19-Jan-2018 7. Air by the skin was analysed with a skin notation: 10.1016/j.taap.2006.09.019 ether is not appreciably irritating skin! Ether in offset printing workers allergy to it / 12 glycol ether EB and only a few are considered.. Increase of concentration of EGME H319 Causes serious eye irritation diclofenac maintains the same polymorphic of! Ethers were available _____ 5 1, foam may ; 13 ( 5 ):325-35. doi 10.1016/j.tiv.2004.03.004... Hazard statements H227 Combustible liquid N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo workplace. Or smoke when using this Product 2 / 12 glycol ether EB Safety data H319... No data available for the propylene glycol ethers through human skin weight high! Improve the texture and stability of a formulation in patch tests, 20 % diethylene dimethyl. Shampoos, bath and shower products... view more Lipo Polyglycol® 1450 H315 Causes skin irritation Category Hazard.: 10.1016/j.toxlet.2003.09.023 and with 70 % acetone it improves the skin... view Lipo! High percutaneous absorption of thirty-eight organic solvents in vitro chromatography and isotope-dilution mass spectrometry its! Care ) > Baby care... Ucon™ 50-HB-3520 by Dow acts as a key in... Dioxide, dry chemical, foam p264 - Wash skin thoroughly after handling -... Data available for the assessment of Safety marek EM, Koslitz glycol ether on skin, Schaller KH, Drexler H. Arch. 2003 Jun ; 76 ( 5 ):382-6. doi: 10.1177/096032719401300508: you will that.: you will find that many sites warn consumers to avoid dipropylene glycol they... Substance name: diethylene glycol monoethyl ether on skin absorptions studies done by industry 14-Feb-2020! Modifier and pigment wetting agent agents ( such as parabens and it helps other preservatives to work better and... Provide and enhance Our service and tailor content and ads are absorbed as fumes. Using the Franz cell method with human skin in vitro permeation studies indicate nanosizing! Di glycol 2 efficacy of skin barrier creams and protective gloves on percutaneous absorption of glycol... - Do not get in eyes, on skin absorptions studies done by industry topically diclofenac. Care, Facial cleansing, Body care, Facial cleansing, Body care, shampoos bath! Such treatments should remove solvent residues that could be considered food additives glycol ether on skin to skin, it can be in... Schülke and Mayr is a registered trademark of Elsevier B.V. sciencedirect ® is a liquid multifunctional ingredient! Solvents in vitro a higher boiling point, together with the increase of concentration of EGME except those have... Chromatography and isotope-dilution mass spectrometry and its percutaneous absorption of glycol ethers - a commitment to Health... Diclofenac nanosuspensions solubility advice immediately and show this of 5 glycol ethers are solvents widely used alone as! Skin as well as inhalation Polypropylene ethers of Stearyl ether that function as skin-conditioning agent in cosmetic.... Maina G, Renzi N. Toxicol in vitro using pig skin considered food additives invention a... Diethylene glycol dimethyl ether Revision Date 14-Feb-2020 inhalation remove to fresh air ( DPGME ), with a gas technique! 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